Epicardial Lineages

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Epicardial Lineages

The epicardium is the mono-layered epithelium that covers the outer surface of the myocardium from early in cardiac development. Long thought to act merely passively to protect the myocardium from frictional forces in the pericardial cavity during the enduring contraction and expansion cycles of the heart, it is now considered to be a crucial source of cells and signals that direct myocardial g...

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Epicardial Activation

were built, with approximately 400,000 microscopic elements arranged in rectangular parallelepipeds in each model. Simulations used the nonlinear Ebihara and Johnson membrane equations for the fast sodium current. Constructed models had histological features of ventricular myocardium. All models were anisotropic. In a subset of the models, an abrupt intramural rotation of the fiber axes was inc...

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Epicardial Origin

Whole-cell voltage-clamp experiments and single-channel current recordings in cell-attached patch mode were performed on enzymatically dissociated single ventricular myocytes harvested from feline endocardial and epicardial surfaces. The studies were designed to compare the characteristics of inward rectifier K' current (IK1) and delayed rectifier K' current (IK) between endocardial and epicard...

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Singular Lineages

Molecular clocks give “Time to most recent common ancestor” TMRCA of genetic trees. By Watson-Galton most lineages terminate, with a few overrepresented singular lineages generated by W. Hamilton’s “kin selection”. Applying current methods to this non-uniform branching produces greatly exaggerated TMRCA. We introduce an inhomogenous stochastic process which detects singular lineages by asymmetr...

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Epicardial versus microcirculatory dissociation.

This exploratory analysis from a well-executed trial of provisional coronary stenting raises two important issues. The first is why should 26% of patients with successful stent implantation have an abnormal coronary flow reserve? Obviously, it is not because of significant residual stenosis (13 12%) or untreated major dissections (4·4% type C or D), but propably because of the ubiquitous disper...

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ژورنال

عنوان ژورنال: Journal of Developmental Biology

سال: 2013

ISSN: 2221-3759

DOI: 10.3390/jdb1010032